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References
- Sex, drugs, and heart failure: a sex-sensitive review of the evidence base behind current heart failure clinical guidelines.ESC Heart Fail. 2018; https://doi.org/10.1002/ehf2.12307
- Heart disease and stroke statistics-2019 update: a report from the American Heart Association.Circulation. 2019; 139: e56-e66https://doi.org/10.1161/CIR.0000000000000659
- Epidemiology of heart failure.Circ Res. 2013; 113: 646-659
- Long-term trends in the incidence of and survival with heart failure.N Engl J Med. 2002; 347: 1397-1402
- Sex-specific epidemiology of heart failure risk and mortality in Europe.JACC Hear Fail. 2019; 7: 204-213
- Trends in heart failure incidence and survival in a community-based population.JAMA. 2004; 292: 344
- Changing incidence and survival for heart failure in a well-defined older population, 1970–1974 and 1990–1994.Circulation. 2006; 113: 799-805
- The impact of gender in cardiovascular medicine: lessons from the gender/sex-issue in heart failure.Monaldi Arch Chest Dis. 2018; 88: 988
- Primary prevention of heart failure in women.JACC Hear Fail. 2019; 7: 181-191
- Neurohormonal and clinical sex differences in heart failure.Eur Heart J. 2013; 34: 2538-2547
- Epidemiology of heart failure with preserved ejection fraction.Nat Rev Cardiol. 2017; 14: 591-602
- Sex and race differences in lifetime risk of heart failure with preserved ejection fraction and heart failure with reduced ejection fraction.Circulation. 2018; 137: 1814-1823
- Predicting heart failure with preserved and reduced ejection fraction.Circ Heart Fail. 2016; 9
- The progression from hypertension to congestive heart failure.JAMA. 1996; 275: 1557-1562
- Role of diabetes in congestive heart failure: the Framingham study.Am J Cardiol. 1974; 34: 29-34
- Sex-specific differences in risk factors for development of heart failure in women.Heart Fail Clin. 2019; 15: 1-8
- Management of patients with heart failure in clinical practice: differences between men and women.Heart. 2008; 94: e10
- Survival trends in men and women with heart failure of ischaemic and non-ischaemic origin: data for the period 1987-2003 from the Swedish Hospital Discharge Registry.Eur Heart J. 2008; 30: 671-678
- Hypertension across a woman’s life cycle.J Am Coll Cardiol. 2018; 71: 1797-1813
- Lifelong gender gap in risk of incident myocardial infarction.JAMA Intern Med. 2016; 176: 1673
- Associations of gender and etiology with outcomes in heart failure with systolic dysfunction.J Am Coll Cardiol. 2007; 49: 1450-1458
- Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency Bisoprolol Study (CIBIS II).Circulation. 2001; 103: 375-380
- Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records.Eur J Heart Fail. 2019; https://doi.org/10.1002/ejhf.1350
- Gender aspects in clinical presentation and prognostication of chronic heart failure according to NT-proBNP and the Heart Failure Survival Score.Clin Res Cardiol. 2015; 104: 334-341
- Sex and gender differences in ischemic heart disease: endocrine vascular disease approach (EVA) study design.J Cardiovasc Transl Res. 2018; https://doi.org/10.1007/s12265-018-9846-5
- Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study.Arch Intern Med. 2001; 161: 996-1002
- Obesity and the risk of heart failure.N Engl J Med. 2002; 347: 305-313
- Sex differences in stroke and major adverse clinical events in patients with atrial fibrillation: a systematic review and meta-analysis of 993,600 patients.Int J Cardiol. 2018; 269: 182-191
- Atrial fibrillation begets heart failure and vice versa.Circulation. 2016; 133: 484-492
- Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study.JAMA. 1994; 271: 840-844
- Comorbidities in heart failure: are there gender differences?.Curr Heart Fail Rep. 2016; 13: 1-12
- Multimorbidity in heart failure: a community perspective.Am J Med. 2015; 128: 38-45
- Heart failure in women. A need for prospective data.J Am Coll Cardiol. 2009; https://doi.org/10.1016/j.jacc.2009.02.066
- Differential impact of heart failure with reduced ejection fraction on men and women.J Am Coll Cardiol. 2019; https://doi.org/10.1016/j.jacc.2018.09.081
- Sex differences in cardiac adaptation to essential hypertension.Eur Heart J. 1989; https://doi.org/10.1093/oxfordjournals.eurheartj.a059434
- Sex-specific cut-offs for high-sensitivity cardiac troponin: is less more?.Cardiovasc Ther. 2019; 2019: 1-12
- Plasma levels of atrial and brain natriuretic peptides in apparently healthy subjects: effects of sex, age, and hemoglobin concentration.Int J Cardiol. 2017; 228: 599-604
- Sex differences of troponin test performance in chest pain patients.Int J Cardiol. 2015; 187: 246-251
- Representation of the elderly, women, and minorities in heart failure clinical trials.Arch Intern Med. 2002; 162: 1682-1688
- Enrollment of older patients, women, and racial and ethnic minorities in contemporary heart failure clinical trials: a systematic review.JAMA Cardiol. 2018; 3: 1011-1019
- Combination of isosorbide dinitrate and hydralazine in blacks with heart failure.N Engl J Med. 2004; 351: 2049-2057
- Aliskiren, enalapril, or aliskiren and enalapril in heart failure.N Engl J Med. 2016; 374: 1521-1532
- Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial.Lancet. 2008; 372: 807-816
- A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure.N Engl J Med. 2001; 344: 1659-1667
- The effect of cardiac resynchronization on morbidity and mortality in heart failure.N Engl J Med. 2005; 352: 1539-1549
- Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme.Lancet. 2003; 362: 759-766
- The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial.Lancet. 1999; 353: 9-13
- Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure.N Engl J Med. 2004; 350: 2140-2150
- Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial.Lancet. 2003; 362: 7-13
- Effects of enalapril on mortality in severe congestive heart failure.N Engl J Med. 1987; 316: 1429-1435
- Effect of carvedilol on survival in severe chronic heart failure.N Engl J Med. 2001; 344: 1651-1658
- Rosuvastatin in older patients with systolic heart failure.N Engl J Med. 2007; 357: 2248-2261
- The effect of digoxin on mortality and morbidity in patients with heart failure.N Engl J Med. 1997; 336: 525-533
- Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE).Lancet. 1997; 349: 747-752
- Eplerenone in patients with systolic heart failure and mild symptoms.N Engl J Med. 2011; 364: 11-21
- Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.N Engl J Med. 2003; 348: 1309-1321
- Irbesartan in patients with heart failure and preserved ejection fraction.N Engl J Med. 2008; 359: 2456-2467
- Cardiac-resynchronization therapy for the prevention of heart-failure events.N Engl J Med. 2009; 361: 1329-1338
- Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.N Engl J Med. 2002; 346: 877-883
- Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF).Lancet. 1999; 353: 2001-2007
- Angiotensin–neprilysin inhibition versus enalapril in heart failure.N Engl J Med. 2014; 371: 993-1004
- The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.Lancet. 2012; 380: 1387-1395
- Angiotensin–neprilysin inhibition in acute decompensated heart failure.N Engl J Med. 2019; 380: 539-548
- The effect of spironolactone on morbidity and mortality in patients with severe heart failure.N Engl J Med. 1999; 341: 709-717
- Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).Eur Heart J. 2005; 26: 215-225
- Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.Lancet. 2010; 376: 875-885
- Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions.N Engl J Med. 1992; 327: 685-691
- Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.N Engl J Med. 1991; 325: 293-302
- Spironolactone for heart failure with preserved ejection fraction.N Engl J Med. 2014; 370: 1383-1392
- The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group.N Engl J Med. 1996; 334: 1349-1355
- A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure.N Engl J Med. 2001; 345: 1667-1675
- Effect of vasodilator therapy on mortality in chronic congestive heart failure.N Engl J Med. 1986; 314: 1547-1552
- A comparison of enalapril with hydralazine–isosorbide dinitrate in the treatment of chronic congestive heart failure.N Engl J Med. 1991; 325: 303-310
- Heart failure in women.Clin Cardiol. 2012; 35: 172-177
- Randomized, double-blind, placebo-controlled study on effects of raloxifene and hormone replacement therapy on plasma no concentrations, endothelin-1 levels, and endothelium-dependent vasodilation in postmenopausal women.Arterioscler Thromb Vasc Biol. 2001; 21: 1512-1519
- Gender differences in the effects of cardiovascular drugs.Eur Heart J Cardiovasc Pharmacother. 2017; 3: 163-182
- Gender related differences in treatment and response to statins in primary and secondary cardiovascular prevention: the never-ending debate.Pharmacol Res. 2017; 117: 148-155
- The sex-specific detrimental effect of diabetes and gender-related factors on pre-admission medication adherence among patients hospitalized for ischemic heart disease: insights from EVA study.Front Endocrinol (Lausanne). 2019; 10https://doi.org/10.3389/fendo.2019.00107
- Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation.JAMA. 2001; 286: 180-187
- Sex-based differences in the effect of digoxin for the treatment of heart failure.N Engl J Med. 2002; 347: 1403-1411
- 2016 ACC/AHA/HFSA focused update on new pharmacological therapy for heart failure: an update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A report of the American College of Cardiology/American Heart Association Task Force on Clinic.Circulation. 2016; 134: e282-e293
- Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial.Lancet. 2009; 374: 1840-1848
- Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis.J Am Coll Cardiol. 2005; 46: 497-504
- Association of serum digoxin concentration and outcomes in patients with heart failure.JAMA. 2003; 289: 871-878
- Sex differences in outcomes and responses to spironolactone in heart failure with preserved ejection fraction: a secondary analysis of TOPCAT trial.JACC Hear Fail. 2019; https://doi.org/10.1016/j.jchf.2019.01.003
- Gender differences in clinical outcome and primary prevention defibrillator benefit in patients with severe left ventricular dysfunction: a systematic review and meta-analysis.Hear Rhythm. 2010; 7: 876-882
- Sex-related differences in patients’ responses to heart failure therapy.Nat Rev Cardiol. 2012; https://doi.org/10.1038/nrcardio.2012.10
- Do women and men respond similarly to therapies in contemporary heart failure clinical trials?.JACC Hear Fail. 2019; https://doi.org/10.1016/j.jchf.2018.12.016
- Reporting sex, gender, or both in clinical research?.JAMA. 2016; 316: 1863-1864
- Consideration of sex differences in medicine to improve health care and patient outcomes.JAMA. 2016; 316: 1865-1866
- What is gender? What is sex?.(Available at:) (Accessed September 26, 2018)
- Better science with sex and gender: a primer for health research.Women’s Health Research Network, Vancouver (Canada)2007
- Comorbidities, sociodemographic factors, and hospitalizations in outpatients with heart failure and preserved ejection fraction.Am J Cardiol. 2018; https://doi.org/10.1016/j.amjcard.2018.01.040
- Socioeconomic factors and mortality in diastolic heart failure.Eur J Clin Invest. 2014; 44: 372-383
- Effect of marital status on clinical outcome of heart failure.J Investig Med. 2013; 61: 835-841https://doi.org/10.2310/JIM.0b013e31828c823e
- Biomarkers in heart failure.N Engl J Med. 2008; 358: 2148-2159
- Prognostic value of emerging neurohormones in chronic heart failure during optimization of heart failure-specific therapy.Clin Chem. 2010; 56: 121-126
- Employment status at time of first hospitalization for heart failure is associated with a higher risk of death and rehospitalization for heart failure.Eur J Heart Fail. 2018; https://doi.org/10.1002/ejhf.1046
- Individual income, mortality and healthcare resource use in patients with chronic heart failure living in a universal healthcare system: a population-based study in Catalonia, Spain.Int J Cardiol. 2018; https://doi.org/10.1016/j.ijcard.2018.10.099
- Community care in England.Circulation. 2012; 126: 1050-1057
- Added value of frailty and social support in predicting risk of 30-day unplanned re-admission or death for patients with heart failure: an analysis from OPERA-HF.Int J Cardiol. 2018; https://doi.org/10.1016/j.ijcard.2018.12.030
- Psychological gender of men with systolic heart failure: a neglected strategy to cope with the disease?.Am J Mens Health. 2014; 8: 249-257https://doi.org/10.1177/1557988313508429
Article Info
Footnotes
This article originally appeared in Heart Failure Clinics, Volume 16, Issue 1, January 2020.
Disclosure Statement: Dr. Raparelli was supported by the Scientific Independence of Young Researchers Program (RBSI14HNVT), Italian Ministry of Education, University and Research (MIUR), Rome, Italy.
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