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Review Article| Volume 24, ISSUE 3, P377-385, August 2006

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Electrocardiographic Diagnosis of Myocardial Infarction during Left Bundle Branch Block

      The diagnosis of myocardial infarction (MI) in the presence of left bundle branch block (LBBB) has long been considered problematic or even almost impossible. Many proposed ECG markers in the old literature have now been discarded. However, the advent of reperfusion therapy has generated greater interest in the ECG diagnosis of acute MI (based on ST-segment abnormalities) [
      • Sgarbossa E.B.
      • Pinski S.L.
      • Barbagelata A.
      • et al.
      for the GUSTO-1 investigators
      Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle branch block.
      ,
      • Sgarbossa E.B.
      Recent advances in the electrocardiographic diagnosis of myocardial infarction: left bundle branch block and pacing.
      ,
      • Sgarbossa E.B.
      Value of the ECG in suspected acute myocardial infarction with left bundle branch block.
      ,
      • Wong C.K.
      • French J.K.
      • Aylward P.E.
      • HERO-2 Trial Investigators
      • et al.
      Patients with prolonged ischemic chest pain and presumed-new left bundle branch block have heterogeneous outcomes depending on the presence of ST-segmentchanges.
      ], although criteria for old MI (based on QRS changes) have not been reevaluated for almost 20 years [
      • Hands M.E.
      • Cook E.F.
      • Stone P.H.
      • the MILIS Study Group
      • et al.
      Electrocardiographic diagnosis of myocardial infarction in the presence of complete left bundle branch block.
      ,
      • Wackers F.J.
      The diagnosis of myocardial infarction in the presence of left bundle branch block.
      ]. Furthermore, analysis of the some of the published data is compounded by the considerable interobserver variability in the interpretation of ECGs [
      • Wackers F.J.
      The diagnosis of myocardial infarction in the presence of left bundle branch block.
      ,
      • Wellens H.J.
      Acute myocardial infarction and left bundle-branch block—can we lift the veil?.
      ,
      • Gula L.J.
      • Dick A.
      • Massel D.
      Diagnosing acute myocardial infarction in the setting of left bundle branch block: prevalence and observer variability from a large community setting.
      ].
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